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Epithelioid trophoblastic tumor of the uterus: Cytological and immunohistochemical observation of a case
Author(s) -
Kamoi Seiryu,
Ohaki Yoshiharu,
Mori Osamu,
Yokoyama Munehiro,
Kawamoto Youko,
Kawamura Takashi,
Araki Tsutomu
Publication year - 2002
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2002.01313.x
Subject(s) - trophoblastic tumor , cytokeratin , human chorionic gonadotropin , human placental lactogen , placental site trophoblastic tumor , immunohistochemistry , pathology , hysterectomy , uterus , nodule (geology) , medicine , epithelioid cell , choriocarcinoma , gynecology , biology , pregnancy , fetus , placenta , gestation , hormone , paleontology , genetics
Epithelioid trophoblastic tumor (ETT) is a new entity of trophoblastic tumor and 14 such cases were reported by Shih and Kurman in 1998. However, only three subsequent cases supporting ETT have been reported. Recently, we experienced a case of ETT in a 37‐year‐old woman whose preoperative endometrial brushings showed atypical mononucleate giant cells and who underwent hysterectomy with the diagnosis of a uterine fibroid. The specimens revealed a 2.5 × 3.0 cm yellow–tan intramural nodule located in the lower uterine segment, which was composed of a neoplastic proliferation of intermediate trophoblasts in epithelioid arrangements. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin and inhibin‐ α , and focally positive for human chorionic gonadotropin and human placental lactogen. She presented an uneventful clinical course as of September 2001.