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Primary low‐grade MALT lymphoma of the gallbladder
Author(s) -
Tsuchiya Tomoshi,
Shimokawa Isao,
Higami Yoshikazu,
Ohtani Hiroshi,
Shigeoka Yuji,
Ohshima Koichi,
Tanaka Kenji,
Ayabe Hiroyoshi
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01299.x
Subject(s) - malt lymphoma , pathology , gallbladder , lymphoma , mucosa associated lymphoid tissue , lymphatic system , medicine , biology , gastroenterology
We report a case of primary low‐grade B‐cell lymphoma of the mucosa‐associated lymphoid tissue (low‐grade MALT lymphoma) in the gallbladder. A 58‐year‐old woman suspected of gallbladder carcinoma underwent laparoscopic cholecystectomy. Microscopic examination of the gallbladder demonstrated lymphoid cell infiltration forming lymphoid follicles with hyperplastic secondary follicles. The surrounding monocytoid B cells and centrocyte‐like cells selectively infiltrated the crypt epithelium forming lympho‐epithelial lesions. Plasma cells were also noted beneath the mucosal epithelium. Bile culture revealed the Gram‐negative bacilli Enterococcus faecalis and Morganella morganii . Immunoglobulin heavy chain gene rearrangement was confirmed using polymerase chain reaction (PCR) and oligoclonal lymphoid proliferations was detected. Because autoimmune diseases, or chronic inflammatory disorders, seem to correlate with the occurrence of MALT lymphoma, Gram‐negative bacterial infection could also be considered as a prodrome of MALT lymphoma of the gallbladder.