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Primary neuroendocrine carcinoma of the liver: An autopsy case
Author(s) -
Kaya Gürkan,
Pasche Christophe,
Osterheld MariaChiara,
Chaubert Pascal,
Fontolliet Charlotte
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01295.x
Subject(s) - chromogranin a , synaptophysin , pathology , autopsy , medicine , neuroendocrine carcinoma , endocrine system , carcinoma , immunohistochemistry , hormone
An autopsy case of primary hepatic neuroendocrine carcinoma is described. A 72‐year‐old man had a large tumor mass measuring 22 cm in its greatest diameter and localized to the right, left and caudal lobes of the non‐cirrhotic liver. Microscopically, the tumor was composed of middle‐sized pleomorphic cells organized in ribbons or trabeculae, with scanty intersecting fibrous septae. Immunohistochemically, the tumor cells were positive for multikeratin C11, chromogranin A and synaptophysin. The patient also had metastases in the bone marrow. No alternative primary source of endocrine tumor was detected. The patient died 4 days after presentation.