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Autopsy case of lymphoplasmacytic lymphoma with a large submucosal tumor in the stomach
Author(s) -
Okada Yoshikatsu,
Mori Hiroshi,
Maeda Tamaki,
Ito Yasuhiro,
Hasegawa Minoru,
Kageyama Takashi
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01274.x
Subject(s) - pathology , lymphoplasmacytic lymphoma , lymphoma , malt lymphoma , medicine , cd5 , stomach , autopsy , lymphatic system , waldenstrom macroglobulinemia , gastroenterology
An autopsy case of lymphoplasmacytic lymphoma with a large submucosal tumor in the stomach is presented. The patient was a 77‐year‐old woman with gastric lymphoma associated with Waldenström’s macroglobulinemia of IgM‐λ type. Diagnosis was initially mucosa‐associated lymphoid tissue (MALT) lymphoma of the stomach, because gastric biopsy specimens showed epitheliotropic proliferation (lymphoepithelial lesion) of the lymphoma cells. Post‐mortem examination revealed a large gastric lymphoma with metastatic foci in the esophagus, larynx, trachea, lungs, spleen and lymph nodes. The bone marrow was also involved. Lymphoma cells consisted of small lymphocytoid cells occasionally admixed with blast‐like large cells and a large number of plasmacytoid or plasma cells. Centrocyte‐like cells were not found. Lymphoepithelial lesions were not conspicuous in autopsy specimens. Immunohistochemically, lymphoma cells reacted with CD20, CD45, CD79a, anti‐IgM, anti‐λ protein and anti‐BCL‐2, but not with CD5, CD10, CD23 or CD38. Based on these findings, the revised diagnosis of the present case was lymphoplasmacytic lymphoma, and it highlighted the differential diagnostic problem from marginal zone B‐cell lymphoma of MALT type.