Premium
Rare case of biphasic tumor of the breast with prominent CD34‐positive spindle cells
Author(s) -
Hayashi Masahiro,
Tamura Gen,
Matsumoto Osamu,
Motoyama Teiichi
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01261.x
Subject(s) - myoepithelial cell , cd34 , pathology , immunohistochemistry , phyllodes tumor , medicine , biopsy , biology , stem cell , genetics
We report an unusual case of biphasic tumor of the breast with prominent CD34‐positive spindle cells. A 53‐year‐old woman presented with a mass in her right breast. Following an incisional biopsy, a partial mastectomy was done. Histologically, the tumor was a biphasic variant of a malignant spindle cell tumor of the breast. The lack of a leaf‐like structure, together with the apparent myoid features of the spindle‐shaped tumor cells, made it difficult to distinguish from malignant phyllodes tumor and from myoepithelial carcinoma. Immunohistochemistry revealed the spindle‐shaped tumor cells to be myofibroblastic, but not myoepithelial in nature, ultimately categorizing this tumor as a malignant phyllodes tumor with prominent myofibroblastic differentiation.