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Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor
Author(s) -
Saito Tsuyoshi,
Oda Yoshinao,
Itakura Eijun,
Shiratsuchi Hideki,
Kinoshita Yoshiaki,
Oshiro Yumi,
Tamiya Sadafumi,
Hachitanda Yoichi,
Iwamoto Yukihide,
Tsuneyoshi Masazumi
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01232.x
Subject(s) - pathology , epithelioid sarcoma , cell adhesion molecule , sarcoma , adhesion , immunohistochemistry , intercellular adhesion molecule 1 , medicine , intracellular , biology , chemistry , immunology , microbiology and biotechnology , organic chemistry
We clinicopathologically evaluated 31 cases of epithelioid sarcoma (ES; 25 ‘classical’ type and six ‘proximal variant’ type) and six cases of malignant rhabdoid tumor (MRT; three extrarenal and three renal). We also did immunohistochemical studies on 12 classical and three proximal variant cases of ES, and six cases of MRT, to clarify the differences in biological behavior in these tumors. E‐cadherin, β‐catenin and CD34 expression was evaluated. We also carried out mutational analysis of exon 3 of the β‐catenin gene by polymerase chain reaction–single‐strand conformation polymorphism analysis. In ES, the 5‐ and 10‐year survival rates were 71.1 and 55.3%, respectively. A high mitotic rate (>15/10 high‐power fields) was significantly correlated with a poor overall survival rate in ES ( P = 0.0248). E‐cadherin expression was observed in nine cases (69.2%) of ES and in four cases (66.7%) of MRT. Most of these tumors showed aberrant E‐cadherin expression. Seven cases (46.7%) of ES were positive for CD34, although none of the cases of MRT were CD34 positive. Eleven cases (73.3%) of ES were positive for β‐catenin, which was localized to the cellular membrane, whereas all of the cases of MRT were β‐catenin negative. Mutational analysis for the β‐catenin gene was done in nine cases of ES and six cases of MRT, however, genetic alteration was not found. From our results, we conclude that β‐catenin membranous expression could be a useful marker for distinguishing ES, including the proximal variant, from MRT.