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Histological diversity of vasculitic lesions in MPO–ANCA‐positive autopsy cases
Author(s) -
Sano Kenji,
Sakaguchi Nobuki,
Ito Makoto,
Koyama Masamichi,
Kobayashi Motohiro,
Hotchi Masao
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01225.x
Subject(s) - panca , medicine , vasculitis , pathology , polyarteritis nodosa , autopsy , arteritis , microscopic polyangiitis , anti neutrophil cytoplasmic antibody , pathological , systemic vasculitis , disease
To investigate the variety of histological features of vasculitic lesions in myeloperoxidase‐specific antineutrophil cytoplasmic antibody (pANCA)‐related vasculitis, retrospective pathological analysis was done on 13 autopsy cases, collected from 1990 to 1998 at five hospitals. These cases were classified into three groups: (i) pulmonary–renal syndrome characterized by capillaritis of lung and glomeruli with occasional small‐vessel arteritis and/or phlebitis; (ii) glomerular capillaritis without pulmonary involvement associated with significant small‐vessel arteritis; and (iii) extensive distribution of small‐vessel arteritis with no capillary involvement. The results suggest that pANCA‐related vasculitis encompasses a wide variety of vasculitic syndromes, including pulmonary–renal syndrome, microscopic polyarteritis nodosa, and classic polyarteritis nodosa. pANCA may contribute to pathogenesis in all of these cases.