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An autopsy case of pancreatic and ectopic nesidioblastosis
Author(s) -
Yasoshima Hitoshi,
Nakata Yasuo,
Ohkubo Eriko,
Matsuno Yasuko,
Sakurai Kazunari,
Kubota Akira,
Minagawa Kyoko
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01209.x
Subject(s) - nesidioblastosis , ectopic pancreas , autopsy , medicine , pancreas , pathology , immunohistochemistry , hyperinsulinemic hypoglycemia , hypoglycemia , insulinoma , endocrinology , diabetes mellitus
We report an autopsy case of pancreatic and ectopic nesidioblastosis. A five‐month‐old Japanese girl was born at 35 weeks gestation, and showed clinical symptoms of hyper‐insulinemic hypoglycemia before death. At autopsy a tumorous nodule was observed at the portion of the jejunum, 90 cm from Treitz’s ligament. The nodule measured 30 × 20 × 20 mm. The ectopic pancreas, also revealed nesidioblastosis histologically. Immunohistologically, both nesidioblastoses were stained positive for chromogranin A, insulin, glucagon and somatostatin. The proliferating cell nuclear antigen (PCNA) and Ki‐67 indices were less than 4% in the nesidioblastosis. To our knowledge, this is the first reported case of nesidioblastosis demonstrating proliferating activity with PCNA and Ki‐67, and is the third reported case of nesidioblastosis arising in the pancreas and ectopic pancreas.