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Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae‐like cyst formation
Author(s) -
Matsumoto Koshi,
Yamamoto Taiichi,
Hisayoshi Takao,
Asano Goro
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01205.x
Subject(s) - medicine , uterus , proliferating cell nuclear antigen , pathology , immunohistochemistry , pathological , uterine leiomyoma , lung , neoplasm , leiomyoma
We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae‐like cystic change. A 53‐year‐old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bullae, a subsequent extirpation of the pulmonary nodules was performed, and a pathological examination showed multiple leiomyomatous nodules with occasional cystic change. A review of the previous slides of the uterus and immunohistochemical analysis of the proliferating ability using anti‐Ki‐67 and anti‐proliferating cell nuclear antigen (PCNA) antibodies were performed. Proliferating cells of the uterus had very few mitotic figures for their high cellularity, and the labeling indices of Ki‐67 and PCNA indicated very low levels in both uterine neoplasm and pulmonary nodules. From these findings, an intravenous leiomyomatosis associated with multiple pulmonary metastases was diagnosed.