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Adult‐onset herpes simplex virus hepatitis with diffuse myofibroblastic transformation of hepatic stellate cells (Ito cells) in non‐necrotic areas
Author(s) -
Toi Makoto,
Kuroda Naoto,
Tao Lihua,
Jin Yulan,
Guo Limei,
Miyazaki Eriko,
Hayashi Yoshihiro,
Hiroi Makoto,
Komatsu Naoki,
Nakata Hideshi,
Ogata Kimiko,
Enzan Hideaki
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01191.x
Subject(s) - hepatic stellate cell , pathology , herpes simplex virus , hepatitis , myofibroblast , immunohistochemistry , necrosis , biology , medicine , virus , virology , fibrosis
The myofibroblastic transformation of hepatic stellate cells (HSC; also known as Ito cells) usually occurs following necrosis of adjacent liver cells. No report has previously found that such a transformation occurs in herpes simplex virus (HSV) hepatitis. We present an autopsy case of HSV hepatitis with myofibroblastic transformation of HSC that is different from the usual transformation of HSC. The patient was a 66‐year‐old woman who had received various therapies for cutaneous T‐cell lymphoma. An autopsy revealed submassive hepatic necrosis with hemorrhage due to HSV hepatitis. HSV infection was confirmed by DNA in situ hybridization in liver tissue. Immunohistochemical staining for α ‐smooth muscle actin (ASMA) showed a strong positive reaction in almost all of the HSC in non‐necrotic areas. However, in necrotic areas, the HSC were completely negative for ASMA. These findings indicate that not only liver cells but also HSC can become necrotic in HSV hepatitis. In contrast, in non‐necrotic areas, almost all of the HSC showed active transformation to myofibroblasts.