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Expression of p21 Waf1 , p27 Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ : Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status
Author(s) -
Oh Young Lyun,
Choi Jong Sun,
Song SangYong,
Ko Young Hyeh,
Han BooKyung,
Nam SeokJin,
Yang JungHyun
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01173.x
Subject(s) - cyclin d1 , ductal carcinoma , immunohistochemistry , estrogen receptor , biology , pathology , comedo , cancer research , breast carcinoma , mammary gland , carcinoma in situ , carcinoma , cell cycle , medicine , breast cancer , cancer
p21 Waf1 (p21), p27 Kip1 (p27) and cyclin D1 have recently been reported as useful prognostic markers for patients with breast carcinoma. However, studies on these cell cycle regulators in ductal carcinoma in situ (DCIS) have been extremely limited. Therefore, we studied the immunohistochemical expression of p21, p27 and cyclin D1 proteins in 49 DCIS cases and compared the findings with the clinicopathologic parameters (age, tumor size, gross type, histologic type, histologic grade, necrosis and mitotic index), p53 and estrogen receptor (ER) status. A significant correlation was found between positive p21 immunoreactivity (67.3% of the cases) and well‐differentiated histologic grade, non‐comedo type, ER‐positive and p53‐negative (p53–) status. DCIS with p21+/p53– is likely to be the non‐comedo type. The overexpression of cyclin D1 (59.2% of the cases) correlated positively with the ER expression ( P = 0.001). The p27 protein expression (46.9% of the cases) correlated with the cyclin D1 immunopositivity ( P = 0.0003) and ER expression ( P = 0.005). No significant associations were seen in the p27 or cyclin D1 expression and other clinicopathologic parameters. Our results suggest that p21 might be more related to the useful biologic markers in DCIS than p27 or cyclin D1. The significant positive association between p21, p27 or cyclin D1 and ER status, and close association of p27 and cyclin D1 expression might be implicated in the tumor biology of DCIS.