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An autopsy case of giant cell myocarditis probably due to a non‐steroidal anti‐inflammatory drug
Author(s) -
Adachi Yasushi,
Yasumizu Ryoji,
Hashimoto Futoshi,
Otsuka Yasunori,
Okamura Akiharu,
Kato Yasushi,
Oyaizu Haruki,
Ikebukuro Kazuya,
Fukuhara Shirou,
Nakai Yoshihide,
Ikehara Susumu
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01166.x
Subject(s) - autopsy , histiocyte , giant cell , myocarditis , medicine , pathology , heart failure , infiltration (hvac) , etiology , disseminated intravascular coagulation , coagulative necrosis , cardiology , physics , thermodynamics
An autopsy case of giant cell myocarditis (GCM) in a 74‐year‐old woman is presented. She suffered from hepatic dysfunction, skin eruption and disseminated intravascular coagulation due to the side‐effects of a non‐steroidal anti‐inflammatory drug. After admission, heart failure progressed rapidly, and the patient died suddenly. At autopsy, her heart was slightly enlarged and the heart muscle was thickened with many small whitish nodules. She was diagnosed with GCM because of the infiltration of multinuclear giant cells, histiocytes, eosinophils and lymphocytes into the heart. We did not find any similar lesions in any other organs. Giant cell myocarditis, the etiology of which is not defined, is a rare disease with unfavorable prognosis. This case suggests the possibility of drug‐induced GCM.