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Histopathological characterization of aortic intimal sarcoma with multiple tumor emboli
Author(s) -
Nishida Naoki,
Yutani Chikao,
IshibashiUeda Hatsue,
Tsukamoto Yoshitane,
Ikeda Yoshihiko,
Nakamura Yoichi
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01144.x
Subject(s) - pathology , vimentin , metastasis , medicine , cytokeratin , aorta , sarcoma , spindle cell sarcoma , epithelioid cell , stromal cell , cancer , immunohistochemistry
A case of aortic intimal sarcoma with multiple tumor emboli and distal metastasis is reported. All metastasis (adrenal, spleen) were via the arteries. This case also had independent lung cancer. Macroscopically, the aortic tumor did not form a bulged mass, but had linear ulceration with abundant mural thrombi. Poorly cohesive large atypical cells were seen in the intima of the abdominal aorta without invasion into the media. Tumor cells were disseminated into the mural thrombi on the aorta and embolized its branches. In the metastatic tumor or tumor emboli of the distal artery, there were not only large atypical cells, but also the foci of spindle‐shaped cells or epithelioid differentiation. Tumor cells in the aorta were immunohistochemically positive for only vimentin. Muscle‐specific actin was positive focally for spindle‐shaped cells of tumor emboli and metastatic tumors. Furthermore, cytokeratin‐positive cells were scatteredly seen. All tumor cells were negative for factor VIII and did not have a histologic or phenotypic analogy with lung cancer. The primary intimal sarcoma in the present case was of undifferentiated non‐endothelial intimal stromal cell origin, and may have had multipotential for differentiation. Investigation of the metastatic site was useful for recognizing the features of this tumor.