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Hepatoid variant of yolk sac tumor of the testis
Author(s) -
Horie Yasushi,
Kato Masako
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01102.x
Subject(s) - pathology , carcinoembryonic antigen , cytokeratin , yolk sac , alpha fetoprotein , eosinophilic , endodermal sinus tumor , lesion , hepatocellular carcinoma , immunohistochemistry , medicine , carcinoma , biology , cancer , embryo , microbiology and biotechnology
A case of testicular yolk sac tumor (endodermal sinus tumor) consisting predominantly of hepatoid cells is documented. A mass measuring approximately 4 × 3 cm was noted in the left testis of a 64‐year‐old man. Preoperative examination revealed an elevated serum level of α ‐fetoprotein (5479 ng/mL). Histologically, the lesion was composed predominantly of sheet‐like or trabecular proliferation of hepatocyte‐like cells with eosinophilic or clear cytoplasm. The tumor cells were immunoreactive for α ‐fetoprotein, antimitochondrial antibody, cytokeratin (AE1/AE3), α ‐1‐antichymotrypsin, α ‐1‐antitrypsin, albumin, carcinoembryonic antigen and epithelial membrane antigen. It was necessary to distinguish this variant lesion from metastatic hepatocellular carcinoma, embryonal carcinoma and hepatoid carcinoma.