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Mucinous carcinoma of the breast with neuroendocrine differentiation
Author(s) -
Nakagawa Hiroyuki,
Shikata Nobuaki,
Senzaki Hideto,
Uemura Yoshiko,
Inoue Tomoo,
Kashu Shin,
Tsubura Airo
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01095.x
Subject(s) - chromogranin a , neuroendocrine differentiation , mucinous carcinoma , pathology , stain , neuroendocrine carcinoma , breast carcinoma , carcinoma , breast cancer , medicine , adenocarcinoma , staining , immunohistochemistry , cancer , prostate cancer
A case of mucinous carcinoma of the breast with neuroendocrine differentiation in an 89‐year‐old woman is presented. The patient presented with a rapidly growing right breast mass, which she had had for 2–3 years. The tumor, 15 × 8 × 5 cm, was located mainly in the upper outer quadrant. Light microscopy revealed a pure mucinous carcinoma of type B. Neuroendocrine differentiation was demonstrated by Grimelius stain and chromogranin A, as well as the presence of neurosecretory granules. The breast cancer cells were of luminal origin and had dedifferentiated to attain neuroendocrine properties.