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A case of atypical granular cell tumor of the neurohypophysis
Author(s) -
Kasashima Satomi,
Oda Yoshio,
Nozaki Junichi,
Shirasaki Masaki,
Nakanishi Isao
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01080.x
Subject(s) - pleomorphism (cytology) , pathology , granular cell tumor , cytoplasm , glial fibrillary acidic protein , atypia , biology , mitosis , tumor cells , nuclear atypia , gfap stain , immunohistochemistry , anatomy , microbiology and biotechnology , medicine , cancer research
A case of granular cell tumor (GCT) arising in the neurohypophysis of a 63‐year‐old woman is reported. The tumor consisted of ovoid, polygonal or spindle‐shaped cells in a sheet‐like or fascicular arrangement. Its abundant cytoplasm contained granules positive for diastase‐resistant periodic acid–Schiff reaction. Ultrastructurally, the tumor cells contained numerous polymorphic lysosomes of various densities. Immunohistochemically, the tumor cells were positive for S‐100 protein, glial fibrillary acidic protein and Leu7, suggesting that the tumor originated from pituicytes that were thought to be modified astrocytes in the neurohypophysis and its stalk. The granular cells showed nuclear atypia, pleomorphism and increased mitotic activity. Therefore, the present tumor was considered as a histologically atypical GCT. Interestingly, proliferating cell nuclear antigen, Ki‐67 and p53 were stained in a few tumor cells of this case. These findings indicate that the present tumor had a malignant potential.