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Anaplastic osteosarcoma with abundant eosinophilic cytoplasm and minimal osteoid production
Author(s) -
Yamamoto Tetsuji,
Marui Takashi,
Mizuno Kosaku,
Kizaki Tomohiko,
Minami Rieko,
Hanioka Keisuke,
Hayashi Yoshitake
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01077.x
Subject(s) - osteoid , vimentin , pathology , eosinophilic , osteosarcoma , cytoplasm , immunohistochemistry , metaphysis , anatomy , chemistry , biology , medicine , microbiology and biotechnology
A case of osteosarcoma with unusual microscopic features, occurring in the right proximal tibial metaphysis of a 12‐year‐old boy is reported. Radiographically, the tumor was ill‐defined and purely osteolytic. On gross examination, the tumor was soft, fragile, spongy and red to brown in color. Microscopically, the tumor consisted of pleomorphic cells possessing abundant eosinophilic cytoplasm, including cells larger than 100 μ m in diameter. The cells were arranged in a sheet, with few extracellular collagen fibers. Multiple sectioning of the specimens revealed a small amount of osteoid production. Immunohistochemical study revealed a positive reaction for vimentin and osteocalcin. Electron microscopic study suggested the fibroblastic or osteoblastic origin of the cells.