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Clear cell sarcoma arising in the transverse colon
Author(s) -
Fukuda Takeaki,
Kakihara Toshio,
Baba Kyoko,
Yamaki Toshifumi,
Yamaguchi Tomiko,
Suzuki Toshimitsu
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01066.x
Subject(s) - pathology , nucleolus , immunohistochemistry , sarcoma , transverse colon , cytoplasm , nodule (geology) , eosinophilic , melanin , biology , medicine , microbiology and biotechnology , paleontology , genetics
A case of clear cell sarcoma (CCS) arising in the transverse colon is presented. The tumor consisted of sheets or small nests of epithelioid malignant cells possessing pleomorphic nuclei with one or more prominent nucleoli and ample clear or slightly eosinophilic cytoplasm. Some of the tumor cells contained various amounts of melanin pigments that were confirmed by histochemical and ultrastructural examinations. Immunohistochemical examination showed a positive immunoreactivity for HMB45 and S‐100 protein. A metastatic nodule, which was found 9 months after surgery, showed similar histological findings to those of the primary one but lacked melanin pigments. Reverse transcriptase– polymerase chain reaction using total ribonucleic acid obtained from metastatic nodule demonstrated the presence of EWS‐ATF‐1 fusion gene. Based on these findings, the present case tumor is a CCS of the colon.