Premium
Bronchial granular cell tumor with osteopontin and osteonectin expression: A case report
Author(s) -
Jin Yulan,
Kuroda Naoto,
Kakiuchi Satoshi,
Yamasaki Yoshikazu,
Miyazaki Eriko,
Hayashi Yoshihiro,
Toi Makoto,
Naruse Keishi,
Hiroi Makoto,
Enzan Hideaki
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01048.x
Subject(s) - osteonectin , osteopontin , pathology , vimentin , stromal cell , granular cell tumor , immunohistochemistry , angiogenesis , cd68 , enolase , medicine , cancer research , biology , immunology , osteocalcin , biochemistry , alkaline phosphatase , enzyme
The case of a 52‐year‐old Japanese man with bronchial granular cell tumors with osteopontin and osteonectin expression is reported here because there have been few investigations of their expression in benign tumors. He was admitted because of sudden hematemesis. A bronchoscopic examination revealed a lobulated polypoid tumor located in the left and right bronchi. Histologically, most tumor cells had abundant granular eosinophilic cytoplasm and were immunoreactive for S‐100, neuron‐specific enolase (NSE), CD68 and vimentin. Moreover, osteopontin‐positive tumor cells were randomly distributed in the tumor tissue, but few stromal cells were positive. In contrast, osteonectin was mainly expressed in the peripheral tumor cells and was also distributed in the stromal cells. Blood vessels at the tumor border in which osteonectin‐positive tumor cells were distributed, proliferated moderately. These results suggest that osteopontin and osteonectin may play a role in the progression of granular cell tumors and in the interaction between the tumor and host or angiogenesis around the tumor, respectively.