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Type VI collagen immunoreactivity in skeinoid fibers in small intestinal stromal tumors
Author(s) -
Tsutsumi Yutaka,
Tazawa Kenichi,
Shibuya Makoto
Publication year - 1999
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.1999.00945.x
Subject(s) - elastin , immunoperoxidase , pathology , desmin , chemistry , vimentin , laminin , fibrillin , glycoprotein , microbiology and biotechnology , extracellular matrix , immunohistochemistry , biology , biochemistry , medicine , immunology , antibody , monoclonal antibody
By immunoperoxidase analysis for types I to VI collagen, elastin, cytoskeletal components and some glycoproteins, we found type VI collagen immunoreactivity in amorphous eosinophilic deposits (skeinoid fibers) in three small intestinal stromal tumors. Negative results were obtained for types I, II, III, IV and V collagen, elastin, laminin, ubiquitin, intracellular filaments such as actin, desmin, vimentin, calponin and caldesmon, and glycoprotein such as lysozyme, factor XIIIa, β2‐microglobulin, α1‐antitrypsin and α1‐antichymotrypsin. In two lesions, the periodic acid‐Schiff‐positive skeinoid fibers were also focally labeled for amyloid P component.