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A clinical and pathological study on the characteristics and factors influencing the prognosis of crescentic glomerulonephritis using a cluster analysis
Author(s) -
Sasatomi Yoshie,
Kiyoshi Yasuhiro,
Takabeyashi Shigeo
Publication year - 1999
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.1999.00943.x
Subject(s) - medicine , pathological , lesion , cluster (spacecraft) , anemia , rapidly progressive glomerulonephritis , pathology , biopsy , glomerulonephritis , kidney , computer science , programming language
Crescentic glomerulonephritis (CrGN) is expressed by a rapidly progressive lesion. However, there is no unanimous view on the factors that affect the prognosis. We carried out a follow‐up study of 109 CrGN patients consisting of 54 males (age 55.3 ± 15.7) and 55 females (age 54.0 ± 16.3) by a cluster analysis using pathomorphological parameters at the time of biopsy, and thus found two categories which were significantly different regarding the speed of progress ( P = 0.0249). The component factors of rapidly progressive CrGN included a combination of several factors such as: (i) a high frequency of crescents; (ii) frequent sclerosis and hyalinosis in the glomeruli with crescents; (iii) extensive tubulo‐interstitial damage (cellular, fibrocellular and fibrous) in the renal cortex; (iv) hyperproteinuria; (v) high mean blood pressure; and (vi) anemia. Thus, the prognosis of CrGN is regulated by no single factor but instead by a complex combination of mutually associated factors.