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Identification of thorotrast by gamma‐spectrometry and simplified autoradiography in pathological specimens
Author(s) -
Yasumizu Ryoji,
Amoh Yasuo,
Ikehara Susumu
Publication year - 1999
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.1999.00931.x
Subject(s) - thorotrast , pathology , pathological , thorium , mass spectrometry , nuclear medicine , medicine , chemistry , materials science , chromatography , uranium , metallurgy
Simplified and reliable methods for identifying thorotrast are demonstrated. On gamma‐ray spectrometry, as little as 0.1 g of liver tissue gives gamma‐ray spectrum characteristics to the thorium decay series, despite a low net count. When conventional film for photography is kept in contact with a paraffin section of the liver for 4 months, it develops silver grains exactly corresponding to the area of granular deposition. By combining this method with clinical and pathological findings, a diagnosis of thorotrastosis can be established without the need for special instruments or materials.