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An evaluative system for the response of antibacterial therapy: Based on the morphological change of Helicobacter pylori and mucosal inflammation
Author(s) -
Wen Min,
Zhang Yali,
Yamada Nobutaka,
Matsuhisa Takeshi,
Matsukura Norio,
Sugisaki Yuichi
Publication year - 1999
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.1999.00868.x
Subject(s) - helicobacter pylori , inflammation , mucosal inflammation , helicobacter , pathology , medicine , immunology
The diagnostic standard is an important factor in the evaluation of the antibacterial effect to Helicobacter pylori (H. pylori) . Few studies have evaluated the bacterial morphological change. In the present study, H. pylori was examined by means of electron microscopy (EM), light microscopy (LM) and immunohistochemical staining. Patients were followed up from 6 weeks to more than 1 year after treatment for H. pylori, and the results of the 13 C‐urea breath test (UBT) were compared. A ‘4‐L’ evaluative system was used for histological diagnosis; that is, complete, significant, partial and negative response for H. pylori treatment. Complete response showed no H. pylori in histology, and positive 13 C‐UBT and negative response showed positive in both diagnoses. A significant response showed the morphology of H. pylori was thick walled by EM, that there was no obvious active inflammation, and was negative for C‐UBT. These H. pylori showed a coccoid form and possibly static bacteria, which was resistant to further antibacterial therapy. The ‘4‐L’ system could evaluate the antibacterial effect, suggesting the necessity for a second line of therapy for H. pylori . It is suggested that this sensitive evaluative system is suitable for clinical applications for antibacterial therapy.