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Obesity affects expression of progesterone receptors and node metastasis of mammary carcinomas in postmenopausal women without a family history
Author(s) -
Honda Hiroshi,
Ohi Yasuyo,
Umekita Yoshihisa,
Takasaki Takashi,
Kuriwaki Kazumi,
Ohyabu Ikuya,
Yoshioka Takako,
Yoshida Aichi,
Taguchi Syuhei,
Ninomiya Kenjirou,
Akiba Suminori,
Nomura Satoru,
Sagara Yoshiatu,
Yoshida Hiroki
Publication year - 1999
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.1999.00846.x
Subject(s) - family history , body mass index , medicine , progesterone receptor , breast cancer , oncology , estrogen receptor , mammary gland , metastasis , cancer , endocrinology , pathology
Possible relationships between risk factors, such as obesity and a family history of breast cancer, and prognostic factors of mammary carcinomas were investigated by examining the body mass index of patients and the expression of estrogen (ER) and progesterone receptors (PgR), c‐erbB‐2 and p53, grade of histology, size of tumors and nodal status of mammary carcinomas. There was no significant difference in the body mass index of premenopausal patients either with or without a family history. For postmenopausal patients, the body mass index was significantly low in patients with a family history compared with patients without a family history. In premenopausal patients with or without a family history and in postmenopausal patients with a family history, there was no significant difference in the body mass index regardless of the mammary carcinoma prognostic factor, such as expression of ER, PgR, c‐erbB‐2 and p53, grade of histology, size of tumors and nodal status. However, in postmenopausal patients without a family history, body mass index was significantly high for patients with mammary carcinomas that had PgR expression and node metastasis. These results suggest that obesity may affect the PgR status and nodal status of mammary carcinomas in postmenopausal patients without a family history.