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Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
Author(s) -
KaramHage Maher,
Brower Kirk J.
Publication year - 2003
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2003.01161.x
Subject(s) - trazodone , bedtime , gabapentin , morning , insomnia , medicine , anesthesia , zopiclone , hypnotic , antidepressant , psychiatry , anxiety , alternative medicine , pathology
Alcohol‐dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4–6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose ± SD = 888 ± 418 mg) at bedtime and 16 were treated with trazodone (105 ± 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.