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Polymorphisms of interleukin‐4 promoter and receptor gene for schizophrenia in the Korean population
Author(s) -
Jun TaeYoun,
Lee KyoungUk,
Pae ChiUn,
Chae JeongHo,
Bahk WonMyong,
Kim KwangSoo,
Han Hoon
Publication year - 2003
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2003.01118.x
Subject(s) - genotype , gene , promoter , genetics , single strand conformation polymorphism , polymorphism (computer science) , allele , schizophrenia (object oriented programming) , microbiology and biotechnology , polymerase chain reaction , receptor , biology , gene expression , medicine , psychiatry
The purpose of the present paper was to investigate the interleukin (IL)‐4 promoter gene −590 and receptor alpha (Rα) gene 1902 polymorphism in Korean schizophrenic patients. A total of 222 Korean patients diagnosed with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM‐IV) and 165 normal healthy controls participated in the present study. The DNA was extracted from whole blood using proteinase K, and the IL‐4 promoter and receptor gene were amplified by polymerase chain reaction. The genotype was determined using single‐strand conformation polymorphism (SSCP) analysis. The distribution of the alleles and genotypes in patients with schizophrenia was not significantly different from those of controls. In conclusion, these results suggest that the polymorphisms in IL‐4 promoter gene −590 and IL‐4 Rα gene 1902 are not involved in the pathophysiology of schizophrenia in the Korean population.