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Interleukin‐10 gene promoter polymorphism is not associated with schizophrenia in the Korean population
Author(s) -
Jun TaeYoun,
Pae ChiUn,
Kim KwangSoo,
Han Hoon,
Serretti Alessandro
Publication year - 2003
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2003.01095.x
Subject(s) - genetics , haplotype , gene , promoter , polymerase chain reaction , restriction fragment length polymorphism , biology , allele , polymorphism (computer science) , population , typing , restriction enzyme , microbiology and biotechnology , medicine , gene expression , environmental health
The present study was aimed at examining the interleukin (IL)‐10 gene promoter region polymorphic variants in patients with schizophrenia in the Korean population. Two hundred and thirty‐three Korean patients diagnosed to have schizophrenia on the basis of Diagnostic and Statistical Manual of Mental Disorders (4th edn; DSM‐IV) and 181 normal healthy controls participated in the present study. The DNA was extracted from whole blood using proteinase K and the IL‐10 gene promoter region was amplified by polymerase chain reaction. Gene typing was performed by restriction fragment length polymorphism and single‐strand conformation polymorphism. Distribution of the alleles and haplotypes in patients with schizophrenia was not significantly different from those of controls. The present study suggests that IL‐10 gene promoter polymorphism is not associated with the development of schizophrenia in the Korean population.