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Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects
Author(s) -
KANBAYASHI TAKASHI,
SUGIYAMA TOMONARI,
AIZAWA RIKA,
SAITO YASUSHI,
OGAWA YURIKO,
KITAJIMA TSUYOSHI,
KANEKO YOSHIHIKO,
ABE MASAHITO,
SHIMIZU TETSUO
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.01008.x
Subject(s) - donepezil , eye movement , rapid eye movement sleep , sleep (system call) , medicine , psychology , ophthalmology , physical medicine and rehabilitation , audiology , dementia , computer science , disease , operating system
Donepezil (Aricept) is a therapeutic drug for the treatment of Alzheimer’s disease (AD). However, there have been only two reports describing the effects of donepezil on sleep as assessed by nocturnal polysomnography (PSG). With this in mind, the effects of donepezil on the sleep of healthy subjects was evaluated using PSG. The results indicated that the percentage of rapid eye movement sleep to total sleep time was increased significantly by a single dose of 5 mg of donepezil when given to healthy subjects immediately before retiring to bed.