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Effects of Yoku‐kan‐san‐ka‐chimpi‐hange on the sleep of normal healthy adult subjects
Author(s) -
AIZAWA RIKA,
KANBAYASHI TAKASHI,
SAITO YASUSHI,
OGAWA YURIKO,
SUGIYAMA TOMONARI,
KITAJIMA TSUYOSHI,
KANEKO YOSHIHIKO,
ABE MASAHITO,
SHIMIZU TETSUO
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.01006.x
Subject(s) - polysomnography , insomnia , sleep (system call) , medicine , slow wave sleep , anesthesia , sleep stages , non rapid eye movement sleep , eye movement , psychiatry , ophthalmology , electroencephalography , apnea , computer science , operating system
Abstract Yoku‐kan‐san‐ka‐chimpi‐hange (YKCH) is a drug used for insomnia in Japanese traditional herbal medicine. The present study evaluated the effects of YKCH on sleep by all‐night polysomnography using the double‐blind method. Yoku‐kan‐san‐ka‐chimpi‐hange increased the total sleep time significantly, and tended to cause an increase in sleep efficiency and of stage 2 sleep, as well as a decrease of sleep latency and of stage 3 + 4 sleep. There was no apparent influence on rapid eye movement (REM) sleep. In terms of non‐REM sleep, the effects of YKCH exhibit a profile similar to those of benzodiazepines.