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Involvement of granulocyte–macrophage colony‐stimulating factor (GM‐CSF) in pregnancy‐enhanced sleep
Author(s) -
KIMURA MAYUMI,
INOUÉ SHOJIRO
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.00968.x
Subject(s) - granulocyte macrophage colony stimulating factor , pregnancy , sleep (system call) , rapid eye movement sleep , granulocyte macrophage colony stimulating factor receptor , medicine , endocrinology , granulocyte , cytokine , granulocyte colony stimulating factor , sleep disorder , immunology , macrophage colony stimulating factor , macrophage , biology , pharmacology , chemotherapy , psychiatry , in vitro , insomnia , electroencephalography , biochemistry , genetics , computer science , operating system
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) is a crucial cytokine for establishing pregnancy. It has been demonstrated previously in rats that sleep increases during early pregnancy and that centrally administered GM‐CSF promotes both rapid eye movement (REM) and non‐REM sleep. Therefore, whether GM‐CSF is involved in pregnancy‐enhanced sleep was investigated using the anti‐GM‐CSF antibody. Female rats received an intracerebroventricular infusion of either anti‐GM‐CSF or control IgG (10 μg each) for four nights from the first day of pregnancy (PD1–PD4). Although sleep amounts on PD1 were not affected, anti‐GM‐CSF decreased non‐REM and REM sleep significantly during PD2–PD4 compared with the control baseline of the IgG group. The results demonstrated that anti‐GM‐CSF treatment suppresses pregnancy‐enhanced sleep, suggesting that GM‐CSF contributes to sleep regulation during pregnancy.