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Methylphenidate hydrochloride for excessive daytime sleepiness in a patient with myotonic dystrophy
Author(s) -
MIYAMOTO TOMOYUKI,
MIYAMOTO MASAYUKI,
SUGA TAKAKO,
AIZAWA CHIE,
TAKEKAWA HIDEHIRO,
HIRATA AND KOICHI
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.00965.x
Subject(s) - myotonic dystrophy , multiple sleep latency test , excessive daytime sleepiness , audiology , methylphenidate , anesthesia , psychology , medicine , cognition , attention deficit hyperactivity disorder , psychiatry , sleep disorder
A 28‐year‐old man with a history of myotonic dystrophy (MyD) is described. His progressively worsening excessive daytime sleepiness (EDS) was treated with methylphenidate hydrochloride. Polysomonography (PSG), the multiple sleep latency test (MSLT), middle latency‐evoked response, and auditory event‐related potentials were used to assess the cause of EDS. The PSG detected small numbers of central sleep apneic episodes. Mean sleep latency, which was determined by MSLT, increased from 5 min before treatment to 14 min after treatment. The Pa, P1, and N1 amplitudes at the Cz site increased after treatment, but P3 latency remained unchanged. These observations suggest that EDS and impairment of cognitive and information processing seen in a patient with MyD may be caused by a central nervous system disorder.