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The study of polysomnography and sleepiness the morning after administration of triazolam and brotizolam
Author(s) -
YAMADERA HIROSHI,
SUZUKI HIDEAKI,
KUDO YOSHIHISA,
ASAYAMA KENTARO,
ITO TAKAO,
ENDO SHUNKICHI
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.00964.x
Subject(s) - triazolam , morning , polysomnography , crossover study , anesthesia , placebo , hypnotic , sleep (system call) , sss* , sleep stages , medicine , multiple sleep latency test , psychology , sleep disorder , psychiatry , insomnia , excessive daytime sleepiness , benzodiazepine , apnea , receptor , alternative medicine , pathology , computer science , operating system
Using polysomnography, sleep effect was studied, then the sleep latency test (SLT), Stanford Sleepiness Scale (SSS), and Kwansei Gakuin Sleepiness Scale (KSS) were studied the next morning after administration of either an inactive placebo (PL), 0.125 mg triazolam (TL), 0.25 mg triazolam (TH), or 0.25 mg brotizolam (BR). Ten healthy male volunteers were used for the double‐blind crossover design. TL increased the percentage of stage 2 sleep significantly compared with PL, whereas TH decreased the number of stage shifts significantly. TH and BR increased the percentage of stage 2 sleep significantly and decreased the percentage of rapid eye movement sleep significantly. Although no drug had any effect on SSS and KSS, BR decreased the sleep latency in SLT significantly.