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Beneficial effects of tandospirone on ataxia of a patient with Machado‐Joseph disease
Author(s) -
Takei Asako,
Honma Sanae,
Kawashima Atushi,
Yabe Ichiro,
Fukazawa Toshiyuki,
Hamada Keiko,
Hamada Takeshi,
Tashiro Kunio
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.00952.x
Subject(s) - ataxia , cerebellar ataxia , anorexia , depression (economics) , anxiety , medicine , psychology , machado–joseph disease , psychiatry , spinocerebellar ataxia , economics , macroeconomics
Tandospirone citrate (tandospirone) is an anti‐anxiety drug that acts by combining with serotonin receptor (5‐hydroxytryptamine‐1 A [5‐HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado‐Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5‐HT1A receptors, were also remarkably alleviated by treatment with tandospirone.