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The relationship between regional cerebral blood flow and the Wisconsin Card Sorting Test in negative schizophrenia
Author(s) -
Liu Zhening,
Tam WaiCheong Carl,
Xie Yaning,
Zhao Jingping
Publication year - 2002
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2002.00924.x
Subject(s) - wisconsin card sorting test , cerebral blood flow , psychology , schizophrenia (object oriented programming) , frontal lobe , cardiology , audiology , medicine , neuroscience , psychiatry , cognition , neuropsychology
The purpose of this study was to explore the relationship between regional cerebral blood flow (rCBF) and problem‐solving thinking in negative schizophrenia. Twenty‐one negative schizophrenic patients and 12 normal controls were studied with single photon emission computed tomography (SPECT). Measures of regional cerebral blood flow (rCBF) were taken both at rest and during a prefrontal activation task using Wisconsin Card Sorting Test (WCST). Compared with controls, poor performances on the WCST of total trials category (TT), perseverative errors (PE) and non‐perseverative errors (NE) were found in negative schizophrenic ( P < 0.05). During WCST activation, patients showed interhemispheric differences in the prefrontal region, but under rest conditions, no such differences manifested. The negative schizophrenia group had a significantly lower rCBF change rate in profrontal lobe during stimulant WCST than those in normal controls ( P < 0.05). The negative schizophrenic patient has executive function deficits and lower rCBF perfusion in left profrontal lobes, which suggest that the negative schizophrenic patient has dysfunction of the left profrontal region.