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Effects of vitamin B 12 on bright light on cognitive and sleep–wake rhythm in Alzheimer‐type dementia
Author(s) -
Ito Takao,
Yamadera Hiroshi,
Ito Ritsuko,
Suzuki Hideaki,
Asayama Kentaro,
Endo Shunkichi
Publication year - 2001
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2001.00860.x
Subject(s) - circadian rhythm , vigilance (psychology) , dementia , actigraphy , rhythm , audiology , medicine , psychology , cognition , endocrinology , neuroscience , psychiatry , disease
The present study investigated the effects of vitamin B 12 (VB 12 ) on circadian rhythm in Alzheimer‐type dementia (ATD). Twenty‐eight ATD patients were treated with bright light therapy (BLT) for 8 weeks. For the latter 4 weeks, half were treated with VB 12 with BLT (BLT + VB 12 ). We evaluated the cognitive state with Mini‐Mental State Examination and the circadian rhythm with actigraphy after the fourth and eighth week. After the first 4 weeks BLT improved the circadian rhythm disturbances and cognitive state especially in the early stage of ATD. Although the latter 4 week‐BLT caused no significant effects on the circadian rhythm; BLT + VB 12 improved the vigilance level during the daytime. These results suggest that VB 12 has some efficiency to enhance vigilance for ATD patients.