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Basal forebrain microinjections of L ‐3,3′,5‐triiodothyronine modify sleep in hypothyroid rats
Author(s) -
Zhang ShiQing,
Martin Joseph V.
Publication year - 2001
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2001.00855.x
Subject(s) - basal forebrain , endocrinology , medicine , triiodothyronine , diagonal band of broca , microinjections , forebrain , preoptic area , sleep (system call) , basal (medicine) , sleep onset , basal ganglia , electroencephalography , hormone , psychology , central nervous system , neuroscience , insomnia , pharmacology , computer science , insulin , operating system
Male rats were injected bilaterally with various doses of L ‐3,3′,5‐triiodothyronine (T 3 ) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8‐h studies. In the medial preoptic area (MPA), a 4 μg dose of T 3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 μg doses of T 3 significantly inhibited non‐REM sleep. Injections to the diagonal band of Broca did not alter EEG‐defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T 3 were demonstrated after acute injections, the data are consistent with possible non‐genomic actions of thyroid hormones in adult brain.