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Melatonin therapy for REM sleep behavior disorder
Author(s) -
Takeuchi Noboru,
Uchimura Naohisa,
Hashizume Yuji,
Mukai Masaki,
Etoh Yoshinori,
Yamamoto Katsuyasu,
Kotorii Tatayu,
Ohshima Hiroharu,
Ohshima Masachika,
Maeda Hisao
Publication year - 2001
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2001.00854.x
Subject(s) - melatonin , parasomnia , clonazepam , rem sleep behavior disorder , psychology , rapid eye movement sleep , sleep (system call) , medicine , sleep disorder , tonic (physiology) , polysomnography , anesthesia , insomnia , psychiatry , electroencephalography , operating system , computer science
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia with clinical symptoms that include punching, kicking, yelling and leaping out of bed in sleep. Polysomnographic (PSG) finding showed REM sleep without muscle atonia. Clonazepam is generally used for treating RBD symptoms but melatonin was reported to be effective so we reconfirmed the effect of melatonin on RBD patients in the present study. We used melatonin (3–9 mg/day) which could ameliorate problem sleep behaviors remarkably, as well as %tonic activity in PSG variables. In the present study, melatonin was reconfirmed to be effective in RBD symptoms, especially for patients with low melatonin secretion, while its mechanism was not clearly known in the present study.