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No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies
Author(s) -
Furuno Taku,
Kawanishi Chiaki,
Iseki Eizo,
Onishi Hideki,
Sugiyama Naoya,
Suzuki Kyoko,
Kosaka Kenji
Publication year - 2001
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2001.00793.x
Subject(s) - dementia with lewy bodies , cyp2d6 , genotyping , genotype , debrisoquine , dementia , allele , genetics , polymorphism (computer science) , allele frequency , medicine , alzheimer's disease , biology , gene , disease
Dementia with Lewy bodies (DLB) is the second most frequent degenerative dementia among the elderly, following Alzheimer‐type dementia (ATD). An association of DLB with CYP2D6 *4, one of the cytochrome P450IID6 (debrisoquine 4‐hydroxylase; CYP2D6) gene polymorphisms, was reported previously, but this is controversial. Moreover, these reports have been restricted to Caucasian populations. Therefore, we compared frequencies of CYP2D6 *3, *4, and *10 mutant alleles in 17 Japanese DLB patients to those among Alzheimer‐type dementia (ATD) patients and healthy controls. Polymerase chain reaction amplification and restriction fragment length polymorphism analyses were used for genotyping. No significant difference of genotype or mutant allele frequencies was detected between DLB, ATD, and healthy controls. The present results do not support the suggestion that the CYP2D6 gene is related to DLB susceptibility, at least in the Japanese population.