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Electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus
Author(s) -
Shen Haowei,
Numachi Yohtaro,
Yoshida Sumiko,
Toda Shigenobu,
Awata Shuichi,
Matsuoka Hiroo,
Sato Mitsumoto
Publication year - 2001
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2001.00788.x
Subject(s) - serotonin transporter , raphe nuclei , dorsal raphe nucleus , serotonin , raphe , electroconvulsive therapy , serotonin plasma membrane transport proteins , medicine , endocrinology , pharmacology , transporter , neuroscience , chemistry , biology , electroconvulsive shock , serotonergic , receptor , gene , biochemistry
The antidepressive actions of electroconvulsive shock (ECS) therapy are considered to involve altered neurotransmission of serotonin. In this study, we investigated the effects of acute and chronic ECS on 5‐hydroxytryptamine (5‐HT) transporter mRNA expression in rat raphe nucleus. We found that serotonin transporter (5‐HTT) mRNA expression was decreased in 9 and 24 h after acute ECS and in 3, 9, 24 h and 2 weeks after chronic ECS in rat raphe nucleus. We presume that the adaptive change in 5‐HTT mRNA expression is possibly related to the therapeutic efficacy of electroconvulsive therapy (ECT) on medication‐resistant depression.