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Auditory P50 obtained with a repetitive stimulus paradigm shows suppression to high‐intensity tones
Author(s) -
Ninomiya Hideaki,
Sato Eigo,
Onitsuka Toshiaki,
Hayashida Takaharu,
Tashiro Nobutada
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00741.x
Subject(s) - stimulus (psychology) , sensory gating , audiology , neutral stimulus , psychology , second order stimulus , gating , neuroscience , stimulus control , perception , visual perception , medicine , cognitive psychology , nicotine
We manipulated stimulus intensity and number of frequency bands in auditory stimuli in order to investigate the nature of P50 in human auditory evoked potentials. Pure‐tone and mixed‐tone conditions were examined. For each condition, four stimulus intensities were used: 55, 70, 85 and 100 dB sound pressure level (SPL). The P50s were obtained at Cz using a repetitive stimulus paradigm. P50 amplitudes increased as stimulus intensities increased up to 85 dB; with 100 dB stimulation amplitudes decreased. The number of frequency bands in the stimulus did not affect P50 amplitude. Considered in terms of P50 suppression under a conditioning/testing paradigm, the results suggest that the P50 wave reflects activity of the sensory gating mechanism in humans.