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Melatonin treatment for circadian rhythm sleep disorders
Author(s) -
Kamei Yuichi,
Hayakawa Tatsuro,
Urata Jujiro,
Uchiyama Makoto,
Shibui Kayo,
Kim Keiko,
Kudo Yoshihisa,
Okawa Masako
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00724.x
Subject(s) - melatonin , circadian rhythm , bedtime , delayed sleep phase , dark therapy , sleep (system call) , chronotype , medicine , sleep disorder , free running sleep , endocrinology , psychology , rhythm , insomnia , psychiatry , circadian clock , light effects on circadian rhythm , computer science , operating system
This study investigated the effects of melatonin administration on circadian rhythm sleep disorders, and aimed to clarify clinical characteristics of melatonin responders. The subjects were 46 patients with circadian rhythm sleep disorders: 30 Delayed Sleep Phase Syndrome (DSPS) and 16 non‐24 h sleep–wake syndrome (non‐24). Patients took 0.3–1.0 mg of melatonin 5, 3 and 1 h before habitual bedtime. Seventeen patients responded to melatonin (12 DSPS, five non‐24). Comparison of clinical background between responders and non‐responders revealed that the responders were characterized by short total sleep time and later onset age of clinical symptoms.