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Effect of 3 mg melatonin on jet lag syndrome in an 8‐h eastward flight
Author(s) -
Takahashi Toshiharu,
Sasaki Mitsuo,
Itoh Hiroshi,
Ozone Motohiro,
Yamadera Wataru,
Hayshida KenIchi,
Ushijima Sadanobu,
Matsunaga Naoki,
Obuchi Keita,
Sano Hidetaka
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00722.x
Subject(s) - lag , melatonin , jet (fluid) , medicine , psychology , neuroscience , physics , mechanics , computer science , computer network
In order to assess the effect of melatonin on jet lag a field study was undertaken. The process of re‐entrainment of circadian melatonin rhythm was investigated in six subjects. Except during 24‐h blood sampling, the subjects were exposed to natural zeitgeber (time giver) outdoors and given 3 mg melatonin at 23:00 h. The subjects were exposed to bright sunlight from 3000 to 12 000 lx. All of them showed orthodromic re‐entrainment with taking melatonin, while two out of the six did not show orthodromic re‐entrainment without taking melatonin. Melatonin accelerated the rate of the re‐entrainment of the circadian melatonin rhythm. Melatonin was useful to jet travel from Tokyo to Los Angeles.