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Predisposing factors in delayed sleep phase syndrome
Author(s) -
Takahashi Yasuro,
Hohjoh Hirohiko,
Matsuura Keiko
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00713.x
Subject(s) - delayed sleep phase , incidence (geometry) , minnesota multiphasic personality inventory , depression (economics) , human leukocyte antigen , sleep (system call) , medicine , genetic predisposition , personality , sleep disorder , psychology , psychiatry , pediatrics , antigen , immunology , disease , insomnia , social psychology , physics , computer science , optics , economics , macroeconomics , operating system
We classified 64 patients with chronic delayed sleep phase syndrome (DSPS) into the primary ( n = 53) and secondary ( n = 11) group according to presence or absence of such signs as difficulty in waking up which appeared much earlier than the onset of DSPS. The age at the onset of the early signs concentrated in adolescence. The familial occurrence of DSPS was noted in 11 patients of the primary group. In human leukocyte antigen (HLA) typing, the incidence of DR1 positivity alone was significantly higher in DSPS patients than in healthy subjects. Minnesota Multiphasic Personality Inventory revealed high scores on depression, psychoasthenia and hypochondriasis. We suggest that a predisposition to DSPS includes biological, genetic, social and psychological factors, various combinations of which may lead to DSPS.