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Effects of small dose of brotizolam on P300
Author(s) -
Hayakawa Tatsuro,
Uchiyama Makoto,
Enomoto Tetsuro,
Nakajima Tsuneo,
Kim Keiko,
Shibui Kayo,
Kudo Yoshihisa,
Ozaki Shigeru,
Nakajima Toru,
Suzuki Hiroyuki,
Urata Jujiro,
Okawa Masako
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00695.x
Subject(s) - placebo , morning , oddball paradigm , medicine , anesthesia , stimulus (psychology) , audiology , event related potential , psychology , electroencephalography , psychiatry , pathology , psychotherapist , alternative medicine
Nine healthy men (mean age, 22.2 years) participated in two experimental sessions cross‐overed randomly in a double blind manner; one with a placebo and the other with 0.125 mg of brotizolam (BTZ) administered in the morning. Resting electroencephalogram and event‐related potential under oddball paradigm was recorded before and 1, 2, 4, 6 and 8 h after the administration. Mean 30‐msec bin amplitude from 240 msec to 450 msec after the stimulus was compared between placebo and drug sessions in order to observe P300. Brotizolam reduced the amplitude of P300 at 6 h after administration. It was noted that the effects of BTZ were most marked at Fz.