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Effects of aniracetam on impaired sleep patterns in stroke‐prone spontaneously hypertensive rats
Author(s) -
Kimura Mayumi,
Okano Shukan,
InouÉ Shojiro
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00693.x
Subject(s) - sleep (system call) , rapid eye movement sleep , medicine , dementia , stroke (engine) , circadian rhythm , slow wave sleep , anesthesia , psychology , endocrinology , eye movement , electroencephalography , psychiatry , ophthalmology , mechanical engineering , disease , computer science , engineering , operating system
The aim of the present study was to determine the pattern of sleep disturbances and the effects on sleep of aniracetam, a cognitive enhancer, in stroke‐prone spontaneously hypertensive rats (SHRSP). Compared with normotensive control rats, SHRSP exhibited an impaired sleep pattern characterized by suppressed diurnal rapid eye movement (REM) sleep and excessive nocturnal non‐REM sleep. At a dose of 30 mg/kg per day p.o., aniracetam increased REM sleep in the light period after administration for 5 consecutive days. Consequently, suppressed REM sleep in SHRSP was restored by repeated treatment with aniracetam. Aniracetam could be useful in improving REM sleep impairment associated with vascular dementia.