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Effects of zolpidem and zopiclone on cognitive and attentional function in young healthy volunteers: An event‐related potential study
Author(s) -
Nakajima Toru,
Takazawa Satoru,
Hayashida Seiki,
Nakagome Kazuyuki,
Sasaki Tsukasa,
Kanno Osamu
Publication year - 2000
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.2000.00634.x
Subject(s) - zopiclone , zolpidem , vigilance (psychology) , hypnotic , morning , psychology , cognition , audiology , event related potential , anesthesia , benzodiazepine , medicine , psychiatry , insomnia , neuroscience , receptor
The effects of zolpidem and zopiclone, non‐benzodiazepine ultra‐short‐acting hypnotics, on cognitive function and vigilance level were investigated in the morning following nocturnal administration using event‐related potentials (ERP) and a sleep latency test (SLT). Zopiclone significantly shortened the sleep latency the following morning, whereas zolpidem did not, perhaps due to the difference in the elimination half‐lives between the compounds. No significant effect was observed for either drug on the ERP indices, including the P3, mismatch negativity and negative difference components. At a clinically prescribed dosage these sleep inducers have no remarkable effect on cognitive or attentional functions but increase sleepiness of the subjects.