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A case of small cerebral cyst and pericentric inversion of chromosome 9 that developed schizophrenia‐like psychosis
Author(s) -
Miyaoka Tsuyoshi,
Seno Haruo,
Itoga Motoi,
Ishino Hiroshi
Publication year - 1999
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1999.00612.x
Subject(s) - psychosis , chromosomal inversion , bipolar disorder , psychology , schizophrenia (object oriented programming) , psychiatry , chromosome 9 , medicine , karyotype , genetics , chromosome , biology , mood , gene
A case of schizophrenia‐like psychosis (psychotic disorder not otherwise specified according to the DSM‐IV criteria) with pericentric inversion on chromosome 9 [inv.(9) (p11; q13)] is reported. In this case, a minor brain anomaly, a small cyst in the left subcortex, was observed on magnetic resonance imaging of the brain. In the clinical course, prominent chronic hallucinations were observed; however, there was no evidence of the disorganization of personality, delusion, and deterioration in level of functioning that are usually seen in schizophrenia. This case and a review of the literature indicate that the pericentric region of chromosome 9 might be a potential areas of interest for the aetiology of psychiatric disorders. The phenotype–karyotype relationship of pericentric inversion on chromosome 9 and its relationship to psychosis are discussed.