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A search for a mutation in the tumour necrosis factor‐alpha gene in narcolepsy
Author(s) -
Kato Tadafumi,
Honda Makoto,
Kuwata Shouji,
Juji Takeo,
Fukuda Masato,
Honda Yutaka,
Kato Nobumasa
Publication year - 1999
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1999.00568.x
Subject(s) - narcolepsy , exon , single strand conformation polymorphism , human leukocyte antigen , gene , genetics , mutation , intron , gene mutation , tumor necrosis factor alpha , biology , alpha chain , microbiology and biotechnology , antigen , immunology , neuroscience , neurology
The discovery of almost 100% association of narcolepsy with human leukocyte antigens (HLA) DR2 antigen prompted molecular biological research of this disorder. In the HLA class II gene cluster, the gene for tumour necrosis factor‐alpha (TNF‐α), which plays a role in the regulation of normal human sleep, is located. The present study searched for a mutation in the TNF‐α gene by single‐strand conformation polymorphism analysis (SSCP) in patients with narcolepsy. No mutation was detected in exons and introns of the TNF‐α gene by SSCP and sequencing.