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Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: Dose‐finding study with no concomitant use of hypnotic agent
Author(s) -
Mashiko Hirobumi,
Niwa ShinIchi,
Kumashiro Hisashi,
Kaneko Yoshihiro,
Suzuki Satoru,
Numata Yoshihiko,
Horikoshi Ryu,
Watanabe Yoshinori
Publication year - 1999
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1999.00532.x
Subject(s) - trazodone , concomitant , bedtime , hypnotic , medicine , drug , anesthesia , psychiatry , psychology , pharmacology , antidepressant , anxiety
This was the first dose‐finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50–100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.