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Effects of a small dose of triazolam on P300
Author(s) -
Hayakawa Tatsuro,
Uchiyama Makoto,
Urata Jujiro,
Enomoto Tetsuro,
Okubo Junji,
Okawa Masako
Publication year - 1999
Publication title -
psychiatry and clinical neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.609
H-Index - 74
eISSN - 1440-1819
pISSN - 1323-1316
DOI - 10.1046/j.1440-1819.1999.00530.x
Subject(s) - triazolam , medicine , benzodiazepine , receptor
Ten healthy men (mean age, 33.9 years) participated in two experimental sessions cross‐overed randomly in a double‐blind manner: one with the placebo and another with 0.125 mg of triazolam (TRZ). Resting electroencephalography and event‐related potential under oddball paradigm were recorded before the drug administration, and 1, 2, 4, 6 and 8 h after that. P300 waveforms were analyzed by peak amplitudes and 30‐ms bin data. Triazolam may cause cognitive dysfunction without general sedation or apparent sleepiness, and this effect appeared 2 h, 4 h and 6 h, most prominently 6 h, after TRZ administration.